In the middle of developing the next Smash Bros. game for Wii U and 3DS, Masahiro Sakurai is reported to be suffering from repetitive strain injury for a lot of hard work. According to Polygon, the Smash Bros. creator has to now use a trackball to work. Sakurai states that his inability to use his arm is getting to “the point where it’s starting to restrict my work and lifestyle.” Along with using a trackball, he’s trying to see if he can issue vocal commands for those he’s supervising. He’s also attempting to use his left arm to work, but it’s not going so well.
Working with mouse and keyboard for extended periods of time can become quite a strain on your arm/wrist. I should know. Twice my left wrist went out of whack, making me unable to do much on work The Wired Fish both late last year and in late 2011. Both times were the result of mice that didn’t conform well to my hand and as a result screwed up my wrist. This never happened to me before 2011, but my time on a computer (which is a lot) probably contributed to my wrist being unfriendly to certain kinds of mice. With a bad wrist (or a bad arm in Sakurai’s case), all you can do is either use your other arm, or just take a break to keep it steady until it’s more functional.
Take a break if you must Sakurai. Last thing we need is someone getting ill from overwork.
Kirby creator gets bad RSI, extols the virtues of trackballs [Polygon, via Siliconera]
The Wired Fish Network 
I had the same problem years ago in college. I did a lot of computer work, and my wrist started getting really strained from it, so much as to where I needed to get a wrist brace to try and alleviate the pain. What I’ve done to try and help prevent pain aside from taking breaks, I stared getting some small weights and doing exercises like rotations and curling to increase strength and range of motion.
There’s also things like ergonomic equipment like those mouse pads with those gel wrist braces to help curb the problem.
Oh God, I recognize that screen and where it’s from. Very subtle.